Vitamin A (VA) regulates the proliferation and differentiation of corneal epithelial cells and preserved conjunctival goblet cells. It has been used in the treatment of disease of the ocular surface. 2–5 Vitamin A regulates the differentiation of the keratoconjunctival epithelium on the ocular surface, is released from the lacrimal gland, and exists in retinol in the tears. Vitamin A or retinol is essential for normal skin development VA is an important regulator of keratinocyte terminal differentiation.
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