Active Natural Ingredients
Withania Somnifera
Withania somnifera (WS) contains Withaferin A, belonging to the steroid class of phytochemicals, is a potent anti-osteoarthritic and anti-inflammatory plant used in Ayurveda, extract inhibited liposaccharyde S induced synthesis of pro-inflammatory cytokines (TNF-alpha, IL-1beta and IL-12) in peripheral and synovial fluid mononuclear cells from rheumatoid arthritis subjects in vitro, but had no effect on IL-6 synthesis. The WS extract also showed inhibitory effects on collagenase activity against the degradation of the bovine Achilles tendon type I collagen, that may be useful in joint disease treatment
Boswellia Serrata
Boswellia or guggul is a small flowering plant native to Central Asia and North Africa. For centuries Ayurvrdic preparations have used the gum extract of the plants to help in managing pain, inflammation and fat metabolism. Boswellia serrata contains four major pentacyclictriterpenic acids (boswellic acids). Boswellic acids seem to be specific inhibitor of 5- lipoxygenase. 5-lipoxygenasegenerates inflammatory leukotrienes, which cause inflammation by promoting free radical damage, calcium dislocation, cell-adhesion and migration of inflammation-producing cells to the inflamed body area.
Curcuma Longa
Turmeric or Curcuma longa is the golden spice so essential in Ayurvdic remedies. Curcuma extracts have been shown to be useful in knee osteoarthritis, reducing the pain and preserving functionality with an efficiency equivalent to ibuprofen. It strongly suppressed joint inflammation and periarticular damage in correlation with decreased activation of NF-κB and of the ensuing cascade of events (involving mediators of inflammation and injury such as chemokines, cyclo oxygenase 2, and receptor activator of nuclear factor kappa-B ligand (RANKL).
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